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 Introduction to Achalasia: Definition, Causes and Symptoms Achalasia is a rare disorder of the esophagus, the muscular tube that connects the throat to the stomach. It affects about 1 in 100,000 people annually. Symptoms usually appear in people between 25 and 60 years old and may include difficulty swallowing, regurgitation of food or liquid, chest pain and heartburn. The cause of achalasia is not known, but it is believed to be related to an abnormal nerve response in the esophagus. The most common symptom is progressive difficulty swallowing solid foods. Other symptoms may include chest pain or pressure, coughing while eating or drinking, and regurgitation of undigested food or liquid. Treatment for achalasia generally involves medications that relax the esophageal muscles and make swallowing easier. Surgery may also be recommended if medications do not help improve symptoms. Surgery is generally considered safe and effective when done by an experienced surgeon. The Bes